ScienceDaily (2010-09-04) -- A multidisciplinary group of researchers has produced a 3.6-angstrom resolution structure of the human adenovirus. Scientists are working with adenovirus as a vector for gene therapy, but have needed better structural information. A multidisciplinary research group at UCLA has now teamed up to not only visualize a virus but to use the results to adapt the virus so that it can deliver medication instead of disease. In a paper published in the journal Science, Hongrong Liu, a UCLA postdoctoral researcher in microbiology, immunology and molecular genetics, and colleagues reveal an atomically accurate structure of the adenovirus that shows the interactions among its protein networks. The work provides critical structural information for researchers around the world attempting to modify the adenovirus for use in vaccine and gene-therapy treatments for cancer.
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